A static list cannot be edited. To deactivate a contact in a static list, you first have to add the contact to the active file. This can be done via an import in the module Lists or by adding the contact manually to the overview Contacts in the module Lists. Look up the contact and deactivate it by using the drop down menu or your right mouse menu.
A newsletter subscriber can always unsubscribe via the unsubscribe link no matter if he or she is included in a static or dynamic list.